Long-duration bed rest as an analog to microgravity

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Long-duration bed rest as an analog to microgravity.

Long-duration bed rest is widely employed to simulate the effects of microgravity on various physiological systems, especially for studies of bone, muscle, and the cardiovascular system. This microgravity analog is also extensively used to develop and test countermeasures to microgravity-altered adaptations to Earth gravity. Initial investigations of bone loss used horizontal bed rest with the ...

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Cardiovascular adaptations to long-duration head-down bed rest.

INTRODUCTION Orthostatic hypotension is a serious risk for crewmembers returning from spaceflight. Numerous cardiovascular mechanisms have been proposed to account for this problem, including vascular and cardiac dysfunction, which we studied during bed rest. METHODS Thirteen subjects were studied before and during bed rest. Statistical analysis was limited to the first 49-60 d of bed rest an...

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Cognitive functioning in long-duration head-down bed rest.

INTRODUCTION This report is one of a series on the Flight Analog Project, which is designed to lay the groundwork for a standard bed rest protocol. The Spaceflight Cognitive Assessment Tool for Windows (WinSCAT) is a self-administered battery of tests used on the International Space Station for evaluating cognitive functioning. Here, WinSCAT was used to assess cognitive functioning during exten...

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Skeletal effects of long-duration head-down bed rest.

INTRODUCTION Skeletal unloading during spaceflight causes regional loss of bone mineral density (BMD), primarily in the spine and lower body regions. This loss of skeletal mass could adversely affect crew health during and after spaceflight and jeopardize mission success. Bed rest has long been used as a spaceflight analog to study the effects of disuse on many body systems, including the skele...

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Dietary support of long-duration head-down bed rest.

INTRODUCTION Dietary control and nutrient intake are critical aspects of any metabolic study, but this is especially true in the case of bed rest studies. We sought to define nutritional requirements, develop menus, and implement them during long-duration head-down bed rest studies. METHODS The dietary goals were to provide 100% of subjects' nutrient requirements and to maintain subjects' bod...

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ژورنال

عنوان ژورنال: Journal of Applied Physiology

سال: 2016

ISSN: 8750-7587,1522-1601

DOI: 10.1152/japplphysiol.00935.2015